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Rod-Shaped Dextran-Coated Nickel-Ferrite Nanoparticles for Use as Contrast Agents in Magnetic Resonance Imaging
New Phys.: Sae Mulli 2018; 68: 290~295
Published online March 30, 2018;
© 2018 New Physics: Sae Mulli.

Da-Ae LEE1, Yusaf IQBAL1, Hongsub BAE1, Ilsu RHEE*1, Sungwook HONG2

1 Department of Physics, Kyungpook National University, Daegu 41566, Korea
2 Division of Science Education, Daegu University, Gyeongsan 38453, Korea
Correspondence to:
Received December 15, 2017; Revised January 14, 2018; Accepted February 6, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Rod-shaped nickel-ferrite (NiFe$_2$O$_4$) nanoparticles were synthesized using a coprecipitation method and were coated with dextran during the synthesis. Transmission electron microscope (TEM) images showed that the average length and width of these particles were 16.86 nm and 3.92 nm, respectively. The coating status of the dextran on the surface of the particles was confirmed by using Fourier-transform infrared spectroscopy. X-ray diffraction measurements showed that the particles had a spinel crystalline structure. The paramagnetic behavior of the particles provided the contrast effects in magnetic resonance imaging (MRI). The $T_1$ and the $T_2$ relaxivities were 2.05 mM$^{-1}\cdot$s$^{-1}$ and 4.92 mM$^{-1}\cdot$s$^{-1}$, respectively. The $T_2$ relaxivity was more than twice the $T_1$ relaxivity. However, the $T_1$ relaxivity value was still appropriate for the application of these particles as $T_1$ contrast agents. These findings show that the rod-shaped particles fabricated in this research can be employed as both $T_1$ and $T_2$ MRI contrast agents.
PACS numbers: 75.20.-g, 81.05.-t, 75.50.Tt, 76.60.-k
Keywords: Nickel-ferrite nanoparticles, Dextran coating, Magnetic resonance imaging contrast agents

July 2018, 68 (7)
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