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Magnetoresistance Properties of Magnetic Nanoparticles and Magnetic Beads Immersed in Physiological Saline Solution and Deionized Distilled Water
New Phys.: Sae Mulli 2019; 69: 883~888
Published online September 30, 2019;
© 2019 New Physics: Sae Mulli.

Jong-Gu CHOI, Byeong-Uk KANG, Sang-Suk LEE*

Department of Oriental Biomedical Engineering, Sangji University, Wonju 26339, Korea
Correspondence to:
Received July 9, 2019; Revised July 22, 2019; Accepted July 22, 2019.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Magnetic nanoparticles (MNPs) and magnetic beads (MBs) were distinguished from each other and mixed with red blood cells (RBCs) and physiological saline solution (PBS). The dependence of the resistance on the structure of and the existence of an external magnetic field were investigated. The MNPs had a diameter of 460~nm in which the carboxyl group ($-$COOH) was attached to the core Fe, and the MBs had an average diameter of about 1~$\mu$m with the Si$-$OH group in the core Fe$ _{3}$O$ _{4}$. Four different types of RBCs combined with 7 to 9 MBs were found to be located at the center and the edge with normal round and abnormal RBC membranes. We observed the appearance of cluster flow in the shape of a swirling cluster when we used a permanent magnet with large amounts of MNPs and MBs combined with RBCs contained in PBS. The resistance values ​​measured for 30~min in a 2.5~cc PBS solution containing 0.5~cc of a solution containing MNPs and MBs showed a different rates of increase that depended on the influence of the external magnetic field. On the other hand, the magnetoresistance ratio (MR) of MBs evenly mixed in deionized distilled water (ddH$ _{2}$O) was changed to about $-$36\% in range of $\pm$1200 Oe.
PACS numbers: 61.46.Df, 75.47.De
Keywords: Magnetic nanoparticles, Magnetic beads, Physiological saline solution(PBS), Deionized distilled water(ddH$ _{2}$O)

September 2019, 69 (9)
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