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https://doi.org/10.3938/NPSM.69.1147
Effects of a Pulsed Magnetic Field on the Blood Flow in a Micro-Channel with Stenosis
New Phys.: Sae Mulli 2019; 69: 1147~1152
Published online November 29, 2019;  https://doi.org/10.3938/NPSM.69.1147
© 2019 New Physics: Sae Mulli.

Seonghyun HAN, Jinwon MOK, Seunghwan BANG, Hyunsook LEE*

Department of Oriental Biomedical Engineering, Sangji University, Wonju 26339, Korea
Correspondence to: hslee@sangji.ac.kr
Received August 8, 2019; Revised September 9, 2019; Accepted September 9, 2019.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This study aims to fabricate a micro-channel with 33% stenosis and a diameter of 15 $\mu$m by using the micro-electro mechanical systems (MEMS) process and polydimethysiloxane (PDMS) and to elucidate the correlation between the blood-flow characteristics and the pulsed magnetic field (PMF) strength and the hematocrit concentration (Ht)%. For Ht from 5% to 45% in blood, the mobility of red blood cell (RBC) increased from 57 to 106% for 1000 G, as well as for 2700 G, compared with the absence of a PMF stimulus. In the micro-channel before and after stenosis, the mobility of the RBC also increased by 40%. Our results suggest that the instantaneous flux change due to the PMF influences the negative charge of the RBC membrane, thereby releasing an aggregation and rouleaux of RBC by increasing the zeta potential, thus contributing to the increased mobility of the RBC. Therefore, these results suggest the possibility of being a PMF as a non-invasive treatment for preventing vascular diseases and for treating blood circulation disorders caused by microvascular narrowing due to stenosis.
PACS numbers: 83.60.Np, 87.50.-a, 85.70.-w, 96.25.Ln
Keywords: PMF(pulsed magnetic field), RBC(red blood cell), Ht(hematocrit), Mobility, Aggregation


November 2019, 69 (11)
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