npsm 새물리 New Physics : Sae Mulli

pISSN 0374-4914 eISSN 2289-0041


Research Paper

New Physics: Sae Mulli 2011; 61: 82-87

Published online January 31, 2011

Copyright © New Physics: Sae Mulli.

T1 and T2 Relaxivities of Hydrogen Protons in an Aqueous Solution of Gold-coated Iron-oxide Nanoparticles

Tanveer AHMAD1, Hong-Sub BAE1, Ilsu RHEE*1, Sungwook HONG2, Jaejun LEE3, Yongmin CHANG3

1Department of Physics, Kyungpook National University, Daegu 702-701
2Division of Science Education, Daegu University, Gyeongsan 712-714
3Department of Diagnostic Radiology, College of Medicine, Kyungpook National University and Hospital, Daegu 700-721



Iron-oxide nanoparticles were synthesized by using the coprecipitation method and were coated with gold. The TEM pictures showed that the shapes of the synthesized nanoparticles were spherical with an average diameter of 20 nm and that the coating thickness of gold was about 2 nm. The T1 and T2 relaxation times of the hydrogen protons in aqueous solutions of the coated nanoparticles were determined by using MRI images. The 1/T1 and 1/T2 versus concentration curves for the nanoparticles showed a linear dependence. The T1 and T2 relaxivities were found to be R1 = 3.1451/mM-sec and R2 = 165.04 1/mM-sec. The ratio of R2/R1 is 52.48, which is about three times larger than those of the commercial MRI contrast agents Resovist and Feridex.

Keywords: Nanoparticles, Relaxation time, MRI contrast agent

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