npsm 새물리 New Physics : Sae Mulli

pISSN 0374-4914 eISSN 2289-0041


Research Paper

New Physics: Sae Mulli 2010; 60: 254-259

Published online February 27, 2010

Copyright © New Physics: Sae Mulli.

Relaxivity of T$_1$ and T$_2$ of Hydrogen Protons in an Aqueous Solution of Silica-coated Iron-oxide Nanoparticles

Tanveer AHMAD1, Ilsu RHEE1*, Sungwook HONG2, Yongmin CHANG3, Jaejun LEE3

1School of Physics and Energy Sciences, Kyungpook National Unversity, Daegu 702-701
2Division of Science Education, Daegu University, Gyeongsan 712-714
3Department of Diagnostic Radiology, College of Medicine, Kyungpook National University and Hospital, Daegu 700-721



Coprecipitated ferrite nanoparticles were coated with silica by using the St$\ddot{o}$ber method. From Transmission Electron Microscope (TEM) pictures, we could see that the coated iron-oxide nanoprticles had a core/shell structure, with the diameter of the shell being about 40 nm and that of the core being about 8 nm. The T1 and T2 relaxation times were measured by  sing magnetic resonance imaging(MRI) scanner for aqueous solutions with various concentrations of nanoparticles. The T1 and T2 relaxivities of hydrogen protons in the aqueous solutions of coated nanoparticles were determined to be R1=0.0034 [1/ppm · sec] and R2=0.066 [1/ppm · sec], respectively. The T2 relaxivity is about 20 times larger than the T1 relaxivity, which indicates that these silica-coated iron-oxide nanoparticles are suitable for use as a T2 contrast agent for MRI.

Keywords: Iron oxide nanoparticles, Silica coating, relaxivity

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