Ex) Article Title, Author, Keywords
New Phys.: Sae Mulli 2020; 70: 1067-1076
Published online December 31, 2020 https://doi.org/10.3938/NPSM.70.1067
Copyright © New Physics: Sae Mulli.
Department of Physics, Pusan National University, Busan 46241, Korea
Growth probabilities of an additional offspring with a beneficial reversal allele were calculated by computer simulation for various population sizes, sequence lengths, selective advantages, and measuring parameters for a finite population in the four-state haploid coupled discrete-time mutation-selection (HCDMS) model. The mutation rates between all sequence elements were set to be equal. This study suggested that the boundary between the deterministic and the stochastic regions in the four-state HCDMS model could be determined by using the same criterion as that in the two-state HCDMS model. For various population sizes, sequence lengths, measuring parameters, and selective advantages, the growth probabilities in the stochastic region could be described using the theoretical formula for the growth probability in the Wright-Fisher two-allele model.
Keywords: Growth probability, Mutation-selection model, Four-state, Asymmetric sharply peaked landscape, Finite population