npsm 새물리 New Physics : Sae Mulli

pISSN 0374-4914 eISSN 2289-0041


Research Paper

New Physics: Sae Mulli 2013; 63: 201-205

Published online February 28, 2013

Copyright © New Physics: Sae Mulli.

Relaxivity of Hydrogen Protons in Aqueous Solutions of Silica-coated Mn-ferrite Nanoparticles Synthesized by Using the Reverse Micelles Method

Tanveer AHMAD1, Sung wook HONG2, Hongsub BAE3, Yousaf IQBAL3, Ilsu RHEE*3

1Department of Physics, Abdul Wali Kahn University, Mardan, Pakistan
2Division of Science Education, Daegu University, Gyeongsan 712-714, Korea
3Department of Physics, Kyungpook National University, Daegu 702-701, Korea



We investigated an innovative approach to develop silica-coated Mn-ferrite nanoparticles by using the reverse micelles method. In transmission electron microscopy (TEM) images the coated nanoparticles were found to be spherical and showed a uniform size distribution with an average diameter of 10nm. The T1 and the T2 relaxation times of the hydrogen protons in aqueous solutions with various concentrations of silica-coated nanoparticles were determined by using a magnetic resonance (MR) scanner. The nanoparticles exhibited a large R2 relaxivity value of 100.1 mM-1sec-1, but a low R1 relaxivity value of 9.49 mM-1sec-1. The relaxivities demonstrated the applicability of silica-coated Mn-ferrite nanoparticles as T2 contrast agents in magnetic resonance imaging (MRI).

Keywords: Mn-Ferrite Nanoparticle, Silica Coating, Relaxivity, Contrast Agent, MRI

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